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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
EU Method A.6 (Water Solubility)
GLP compliance:
Type of method:
flask method
Water solubility:
ca. 0.057 g/L
Conc. based on:
test mat.
20 °C
ca. 7.96
Remarks on result:
Mean value of three flasks

Table 9.2 : Analytical Determinations

 Flask No.

 Dilution factor  pH  Peak area 1  Peak area 2  Mean concentration (g/l)
 1  1  4.60  1168404  1170673  0.057
 2  1  4.49  1123255  1117310  0.054
 3  1  4.46  1255744  1252581


Mean water solubility: 0.057 g/l
Executive summary:

The water solubility was appraised using computer software which uses the chemical structure to provide an estimated value. The water solubility estimation was performed using EPI Suite software package in accordance with test guidance. The estimated water solubility was 0.171 - 0.237 g/l.

For the formal solubility test, the flask method was used, based on the results of the earlier calculations and according to the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A6. The mean water solubility was measured at 0.057 g/l.

Description of key information

Water solubility measured using flask method, according to the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A6. Mean water solubility was found to be 0.057 g/L at 20C.

Key value for chemical safety assessment

Water solubility:
0.057 g/L
at the temperature of:
20 °C

Additional information