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EC number: 256-062-6
CAS number: 43048-08-4
No reproduction data is available on Tricyclodecane dimethanol dimethacrylate. However in the screening study on reproduction on an analogue substance (Tricyclodecane dimethanol diacrylate), the test substance was administered daily by oral gavage to male and female Sprague Dawley rats, for 2 weeks before pairing, during pairing, gestation and until day 5 p.p., at dose-levels of 100, 300 or 1000 mg/kg/day.No adverse effect was observed in this study at any doses. Therefore, based on the experimental conditions of this study: the NOAEL for parental toxicity, the NOAEL for reproductive performance (mating and fertility) and the NOAEL for toxic effects on progeny were 1000 mg/kg/day.
Screening reproduction study (Bentz 2015,
OECD 421), read-across on analogue substance
objective of this study was to evaluate the potential toxic effects of
Tricyclodecane dimethanol diacrylate following daily oral administration
(gavage) to male and female rats from before mating, through mating and,
for females, through gestation until Day 4 post-partum (p.p.).
This study provides initial information on male and female reproductive
performance, such as gonadal function, mating behavior, conception,
development of the conceptus and parturition.
groups of ten male and ten female Sprague-Dawley rats received the test
item daily by oral (gavage) administration before mating, through mating
and, for the females, through gestation until Day 4p.p.. The test item
was administered as a solution in the vehicle, corn oil, at dose-levels
of 100, 300 or 1000 mg/kg/day. Another group of ten males and ten
females received the vehicle alone, under the same experimental
conditions and acted as a control group. A constant dose-volume of 5
mL/kg/day was used.
were no unscheduled deaths ascribed to test item treatment. Test
item-related clinical signs were limited to ptyalism which was noted in
several animals given 300 mg/kg/day and in all animals given 1000
mg/kg/day and was considered to be of minor toxicological relevance.
There were no test item treatment-related effects on mean body weight,
mean food consumption, mean organ weights and at macroscopic and
were no test item treatment-related effects on mating and fertility
data, mean duration of gestation, mean number of corpora lutea, mean
number of implantations, mean percentage of pre-implantation loss and
mean number of pups delivered. At 1000 mg/kg/day, there was a trend
towards a slightly high mean percentage of post-implantation loss
(14.6%vs.6.9% in controls) due to 2/10 females; this effect was
considered to be non-adverse because no effects on the mean number of
pups per litter were observed.
were no toxicologically significant effects on pup data (viability, mean
body weight, sex ratio, macroscopic findings). A relationship of the
clinical signs noted in one litter mainly (blackish abdomen,
hypoactivity, cold to the touch and dehydration) with the test item
treatment was considered to be doubtful.
the experimental conditions of this study:
the No Observed Adverse Effect Level (NOAEL) for parental systemic
toxicity and reproductive performance was considered to be 1000
mg/kg/day, based on the absence of adverse effects at all dose-levels,
the NOAEL for toxic effects on progeny was considered to be 1000
mg/kg/day, based on the absence of adverse effects in pups at all
Based on the results available on Tricyclodecane dimethanol diacrylate
(no effect on reproductive organs in male and female rats in the 28 -day
repeated study, and no effects on the reproduction in the screening
study), no classification for Tricyclodecane dimethanol dimethacrylate
is required for reprotoxicity according to the Regulation EC n°1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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