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EC number: 256-062-6
CAS number: 43048-08-4
The tesst item Tricyclodecane-dimethynole-dimethacrylate was assessed
for it potential to induce primary DNA-breakage according to the single
cell gel electrophoresis (comet assay) with Chinese hamster V79 -cells.
The assay was performed with and without liver microsomal activation.
Negative and positive controls were all in the range to ensure a correct
performance of the comet assay. The parallel performed FDA-test for cell
viability showed no reduction in cell viability in all test groups with
and without metabolic activation. No increase of the mean tailmoment was
observed following treatment with the test item at the three tested
doses with and without metabolic activation.
In conclusion, it can be stated that in this study and under the
reported experimental conditions, the test item did not induce primary
DNA-breakage in V79 cells with and without metabolic activation.
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