(octahydro-4,7-methano-1H-indenediyl)bis(methylene) bismethacrylate

Endpoint summary

Description of key information

No experimental toxicokinetic study is available on Triclyclodecanedimethanol dimethacrylate. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties and QSAR predictions.
Based on the toxicological data, the physicochemical properties and the QSAR predictions, the absorption of Triclyclodecanedimethanol dimethacrylate is expected to be high by oral route and inhalation, but low by dermal route.

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

100

Absorption rate - dermal (%):

10

Absorption rate - inhalation (%):

100

Additional information

No experimental toxicokinetic study is available on Triclyclodecanedimethanol dimethacrylate. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:

-Mean molecular weight: 332.4 g/mol

-Water solubility: 0.39 mg/L

-Partition coefficient (Log Kow): 5.8

-Vapour pressure: 0.0109 Pa

 

ABSORPTION

Oral absorption

The high value of log Kow (>4) and the low solubility (<100 mg/L) of Triclyclodecanedimethanol dimethacrylate are favorable for a low oral absorption. Using a model to predict either high or low fraction absorbed for an orally administered, passively transported substance, the rates of absorption of test substance were 100 and 90% for a dose of 1 and 1000 mg, respectively (Danish QSAR). According to the model "Intestinal absorption (human)" (pkCSM), 96 % of the substance is absorbed after oral exposure.

An oral absorption of 100 % is taken into account for risk assessement

 

Dermal absorption

With a solubility of 0.39 mg/L, dermal absorption is anticipated to be low. A Log Kow of 5.8 suggests that the rate of penetration of the substance may be limited by the rate of transfer between the stratum corneum and the epidermis. However, a molecular mass smaller than 500 g/mol are favourable to a dermal absorption. The acrylates are known to bind to skin components, and this binding decreases their dermal absorption.

According to the IH Skin Perm (QSAR), the dermal absorption of the substance is estimated to be low (<= 10%).

Triclyclodecanedimethanol dimethacrylate showed allergic reaction in the skin sensitisation study: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose.

A dermal absorption of 10 % is taken into account for risk assessement

 

Inhalation absorption

Based on the low value of the vapour pressure (<0.1 Pa), Triclyclodecanedimethanol dimethacrylate is not considered as a volatile substance. Moreover, the absorption by inhalation can be expected to be low for Triclyclodecanedimethanol dimethacrylate based on the values of water solubility and log kow.

An absorption by inhalation of 100 % is taken into account for risk assessement

 

DISTRIBUTION

No experimental data is available on the distribution of Triclyclodecanedimethanol dimethacrylate.

According to the models in pkCSM, the volume of distribution is moderate, only 8.9% of the absorbed dose is unbound in the plasma, and the substance is cross moderately the blood-brain barrier.

 

METABOLISM

No experimental data is available on the metabolism of Triclyclodecanedimethanol dimethacrylate.

 

ELIMINATION

Due to the low water solubility and the moderate molecular mass, the excretion of Triclyclodecanedimethanol dimethacrylate in the urines is expected to be low. An excretion via bile and faeces is possible.

According to the pkCSM models, the substance is not transported by the renal transporter " OCT2", and, a high predicted total clearance (hepatic & renal clearance) is expected.