(diethylamino)acetonitrile

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

prior to GLP and OECD TG

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

prior to GLP and OECD TG

Principles of method if other than guideline:

According to BASF-internal standard.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

(diethylamino)acetonitrile

EC Number:

221-130-6

EC Name:

(diethylamino)acetonitrile

Cas Number:

3010-02-4

Molecular formula:

C6H12N2

IUPAC Name:

2-(diethylamino)acetonitrile

Details on test material:

Name of the test substance used in the study report: Produkt 73/127 dest. (= Diaethylaminoacetonitril dest.)

Test animals

Species:

rabbit

Strain:

Vienna White

Sex:

male/female

Details on test animals or test system and environmental conditions:

2 of the animals were purchased and 1 animal was bred.

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

The substance was applied on the back. Application area: 50 cm2.

Doses:

0.2 mL undiluted test substance

No. of animals per sex per dose:

3

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

< 174 mg/kg bw

Based on:

test mat.

Remarks on result:

other: original value: < 0.2 mL/kg

Effect levels 2

Sex:

male/female

Dose descriptor:

LD100

Effect level:

<= 174 mg/kg bw

Based on:

test mat.

Remarks on result:

other: original value: < 0.2 mL/kg

Mortality:

Two animals died within 25 minutes. The third animal died after about 50 minutes.

Clinical signs:

After about 10 minutes in all three animals rapid breathing was observed. Shortness of breath was observed after another 10 minutes togerther with crying and severe apathy.

Gross pathology:

heart: acute dilatation and congestive hyperemia; lung: slightly edematised

Applicant's summary and conclusion

Interpretation of results:

Category 2 based on GHS criteria