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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
prior to GLP and OECD TG

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
prior to GLP and OECD TG
Principles of method if other than guideline:
According to BASF-internal standard.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(diethylamino)acetonitrile
EC Number:
221-130-6
EC Name:
(diethylamino)acetonitrile
Cas Number:
3010-02-4
Molecular formula:
C6H12N2
IUPAC Name:
2-(diethylamino)acetonitrile
Details on test material:
Name of the test substance used in the study report: Produkt 73/127 dest. (= Diaethylaminoacetonitril dest.)

Test animals

Species:
rabbit
Strain:
Vienna White
Sex:
male/female
Details on test animals or test system and environmental conditions:
2 of the animals were purchased and 1 animal was bred.

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The substance was applied on the back. Application area: 50 cm2.
Doses:
0.2 mL undiluted test substance
No. of animals per sex per dose:
3
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
< 174 mg/kg bw
Based on:
test mat.
Remarks on result:
other: original value: < 0.2 mL/kg
Sex:
male/female
Dose descriptor:
LD100
Effect level:
<= 174 mg/kg bw
Based on:
test mat.
Remarks on result:
other: original value: < 0.2 mL/kg
Mortality:
Two animals died within 25 minutes. The third animal died after about 50 minutes.
Clinical signs:
After about 10 minutes in all three animals rapid breathing was observed. Shortness of breath was observed after another 10 minutes togerther with crying and severe apathy.
Gross pathology:
heart: acute dilatation and congestive hyperemia; lung: slightly edematised

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria