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EC number: 221-130-6
CAS number: 3010-02-4
Significant accumulation in organisms is not to be expected.
on a measured partition coefficient of 0.48 (at 25°C; BASF AG, 1998;
report: 104217/04), (diethylamino)acetonitrile has a low potential for
bioaccumulation or bioconcentration.
accordance with column 2 of Annex IX, the study on "bioaccumulation in
aquatic species, preferably fish" does not need to be conducted if the
substance has a low potential for bioaccumulation (for instance a log
Kow <= 3) and/or a low potential to cross biological membranes.
has a low potential for bioaccumulation as the log Kow was measured to
be < 3. Therefore, and for reasons of animal welfare, no bioaccumulation
test with fish is conducted.
addition, according to chapter 2, article 17 of REACH regulation (EC)
no. 1907-2006, a study is not required for on-site isolated
in order to assess the bioaccumulation potential of the test substance,
the BCF was calculated with several estimation models. The table below
lists the applied (Q)SAR models, the estimated BCF values and basic
information on the applicability domain (AD). Detailed information on
the model’s results and the AD are given in the endpoint study records
of IUCLID Chapter 5.3.1. The selected models comply with the OECD
principles for (Q)SAR models.
of relevant information on aquatic bioaccumulation: Predicted BCF values
for applied QSAR models sorted by BCF (AD = Applicability Domain)
BCF Read-Across v1.0.2
the highest similarity value found for similar compounds is notadequate
(EPI Suite v4.11):Arnot-Gobas BCF, upper trophic, incl. biotransformation
The substance ionizes at physiologically relevant pH
(EPI Suite v4.11):Arnot-Gobas BCF, upper trophic, incl. biotransformation of zero
US EPA T.E.S.T. v4.1: Bioaccumulation: Consensus method
OASIS Catalogic v5.11.16(BCF base-line model v02.08)
Incl. all mitigating factors
Meylan v1.0.2(VEGA v1.0.8)
only moderately similar in the training set have been found; the reliability of log P value is not adequate.
(EPI Suite v4.11):Meylanet al.(1997/1999)
without any mitigating factors
on a weight-of-evidence approach from calculated data, it can be
concluded that significant accumulation in organisms is not to be
Article 13 of Regulation (EC) No 1907/2006, it is laid down that
information on intrinsic properties of substances may be generated by
means other than tests, provided that the conditions set out in Annex XI
(of the same Regulation) are met. Furthermore according to Article 25 of
the same Regulation testing on vertebrate animals shall be undertaken
only as a last resort.
to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used
if (1) the scientific validity of the (Q)SAR model has been established,
(2) the substance falls within the applicability domain of the (Q)SAR
model, (3) the results are adequate for the purpose of classification
and labeling and/or risk assessment and (4) adequate and reliable
documentation of the applied method is provided.
the assessment of (diethylamino)acetonitrile
(Q)SAR results were used for aquatic bioaccumulation.The
criteria listed in Annex XI of Regulation (EC) No 1907/2006 are
considered to be adequately fulfilled and therefore the endpoint(s)
sufficiently covered and suitable for risk assessment.
and for reasons of animal welfare, further experimental studies on
aquatic bioaccumulation are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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