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EC number: 221-130-6 | CAS number: 3010-02-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
Based on a measured partition coefficient of 0.48 (at 25°C; BASF AG, 1998; report: 104217/04), (diethylamino)acetonitrile has a low potential for bioaccumulation or bioconcentration.
In accordance with column 2 of Annex IX, the study on "bioaccumulation in aquatic species, preferably fish" does not need to be conducted if the substance has a low potential for bioaccumulation (for instance a log Kow <= 3) and/or a low potential to cross biological membranes.
(Diethylamino)acetonitrile has a low potential for bioaccumulation as the log Kow was measured to be < 3. Therefore, and for reasons of animal welfare, no bioaccumulation test with fish is conducted.
In addition, according to chapter 2, article 17 of REACH regulation (EC) no. 1907-2006, a study is not required for on-site isolated intermediates.
However, in order to assess the bioaccumulation potential of the test substance, the BCF was calculated with several estimation models. The table below lists the applied (Q)SAR models, the estimated BCF values and basic information on the applicability domain (AD). Detailed information on the model’s results and the AD are given in the endpoint study records of IUCLID Chapter 5.3.1. The selected models comply with the OECD principles for (Q)SAR models.
Summary of relevant information on aquatic bioaccumulation: Predicted BCF values for applied QSAR models sorted by BCF (AD = Applicability Domain)
Model |
BCF |
In AD |
Restraints |
BCF Read-Across v1.0.2 (VEGA v1.0.8) |
1 |
no |
the highest similarity value found for similar compounds is notadequate |
BCFBAF v3.01 (EPI Suite v4.11):Arnot-Gobas BCF, upper trophic, incl. biotransformation |
1 |
no |
The substance ionizes at physiologically relevant pH |
BCFBAF v3.01 (EPI Suite v4.11):Arnot-Gobas BCF, upper trophic, incl. biotransformation of zero |
1.2 |
no |
The substance ionizes at physiologically relevant pH |
CAESAR v2.1.13 (VEGA v1.0.8) |
2 |
yes |
- |
US EPA T.E.S.T. v4.1: Bioaccumulation: Consensus method |
2.3 |
yes |
- |
OASIS Catalogic v5.11.16(BCF base-line model v02.08) Incl. all mitigating factors |
2.4 |
yes |
- |
Meylan v1.0.2(VEGA v1.0.8) |
3 |
no |
only moderately similar in the training set have been found; the reliability of log P value is not adequate. |
BCFBAF v3.01 (EPI Suite v4.11):Meylanet al.(1997/1999) |
3.2 |
yes |
- |
OASIS Catalogic v5.11.16(BCF base-line model v02.08) without any mitigating factors |
11.4 |
yes |
- |
Based on a weight-of-evidence approach from calculated data, it can be concluded that significant accumulation in organisms is not to be expected.
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of (diethylamino)acetonitrile (Q)SAR results were used for aquatic bioaccumulation.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.