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Registration Dossier
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EC number: 221-130-6 | CAS number: 3010-02-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- prior to GLP and OECD TG, restricted reporting
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list IV
- Author:
- Smyth H.F. et al.
- Year:
- 1 951
- Bibliographic source:
- AMA Arch. Ind. Hyg. Occup. Med. (1951) 4(2), 119-122
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal (1962), Vol 23, pg. 95-107
Materials and methods
- Principles of method if other than guideline:
- Rats are exposed to the test substance by inhalation (vapour) and observed for 14 days.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- (diethylamino)acetonitrile
- EC Number:
- 221-130-6
- EC Name:
- (diethylamino)acetonitrile
- Cas Number:
- 3010-02-4
- Molecular formula:
- C6H12N2
- IUPAC Name:
- 2-(diethylamino)acetonitrile
- Details on test material:
- - Name of test material (as cited in study report): N,N-Diethylaminoacetonitrile
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation: vapour
- Details on inhalation exposure:
- Inhalation of metered vapor concentrations by rats is conducted with flowing streams of vapor prepared by various styles of proportioning pumps. Concentrations are in an essentially logaritmic series with a factor of two.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 62 and 125 ppm
- No. of animals per sex per dose:
- 6 animals per dose, sex unknown
- Details on study design:
- 14 day observation period
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 62 - 125 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 0.29 - 0.58 mg/L
- Mortality:
- All rats survived a concentration of 62 ppm. None of the rats survived exposure to 125 ppm.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
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