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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
prior to GLP and OECD TG, restricted reporting

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: list IV
Author:
Smyth H.F. et al.
Year:
1951
Bibliographic source:
AMA Arch. Ind. Hyg. Occup. Med. (1951) 4(2), 119-122
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth H.F. et al.
Year:
1962
Bibliographic source:
American Industrial Hygiene Association Journal (1962), Vol 23, pg. 95-107

Materials and methods

Principles of method if other than guideline:
Rats are exposed to the test substance by inhalation (vapour) and observed for 14 days.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(diethylamino)acetonitrile
EC Number:
221-130-6
EC Name:
(diethylamino)acetonitrile
Cas Number:
3010-02-4
Molecular formula:
C6H12N2
IUPAC Name:
2-(diethylamino)acetonitrile
Details on test material:
- Name of test material (as cited in study report): N,N-Diethylaminoacetonitrile

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation: vapour
Details on inhalation exposure:
Inhalation of metered vapor concentrations by rats is conducted with flowing streams of vapor prepared by various styles of proportioning pumps. Concentrations are in an essentially logaritmic series with a factor of two.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
62 and 125 ppm
No. of animals per sex per dose:
6 animals per dose, sex unknown
Details on study design:
14 day observation period

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
62 - 125 ppm
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: 0.29 - 0.58 mg/L
Mortality:
All rats survived a concentration of 62 ppm. None of the rats survived exposure to 125 ppm.

Applicant's summary and conclusion

Interpretation of results:
Category 1 based on GHS criteria