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EC number: 231-150-7
CAS number: 7440-41-7
For the Reading (PA, USA) plant and based on a total of 7347 analyses
performed between 1947 and 1992 (6943 analyses between 1971 and 1992)
with different methodologies the Daily Weighted Average (DWA). Exposure
estimates, types and form of beryllium and potential confounders were
calculated or extrapolated for 4 different periods (1953 -1960, 1961
-1970, 1971 -1980, 1981 -1992). For 325 different job descriptions
exposure was established for cumulative beryllium exposure while
employed at Reading. The number of days of exposure, cumulative
exposure, average exposure and maximum exposure to each of the types of
beryllium (beryl ore, beryllium fluoride, beryllium hydroxide, beryllium
oxide, beryllium-copper alloy- and each form of beryllium aerosol-dust,
fume, or mixed-were calculated for each case and control. These exposure
metrics were calculated using the same methods as used to calculate
total beryllium exposures, except that job exposures only contributed to
the exposure metrics for the various types and forms of beryllium
associated with that job.
The number of days that the cases and controls were exposed to chemical
agents which might confound or modify the observation of an association
between beryllium and lung cancer were also calculated. Because no
measurement data were available for these agents, only the number of
days that the worker had been employed in jobs which might encounter
exposure to the potential confounder.
Exposures were variable from job to job, but regularly declining by
period of observation (1953-1960, 1961-1970, 1971-1980, 1981-1992) at
statistically significant levels.
The cumulative exposure correlates with tenure (r = 0.84), average and
maximum exposure correlate (r = 0.90).
Average and maximum exposure do not correlate with duration of
employment or cumulative exposure.
The expsoure data (not reported) were used in the companion study
Sanderson et al. (2001b), a nested case-control study.
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