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EC number: 231-150-7
CAS number: 7440-41-7
of revertants per plate (mean of 3 plates); Experiment I
*solvent control with
of revertants per plate (mean of 3 plates); Experiment II
with 0.9% NaCl
The mutagenic potential of beryllium metal powder was investigated in an
Ames test according to OECD guideline 471. Briefly, bacteria (S.
typhimurium TA1535, TA1537, TA98, TA 100 and E. coli WP2 uvrA) were
exposed to the test item in presence and absence of metabolic activation
(rat liver S9) and grown on selective agar plates, eliminating bacteria
without mutations. The colonies formed from surviving (= mutant)
bacteria were counted.
Beryllium metal was - due to its insolubility in aqueous media at
neutral pH - extracted in physiological saline and the extracts were
applied to expose the bacteria. In the first expereiment the
pre-incubation and in the second experiment the plate incorporation
method were used.
No increases of mutant numbers were observed in treated groups compared
to control. The test item was non-mutagenic in the bacterial reverse
mutation assay under the test conditions.
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