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EC number: 231-150-7
CAS number: 7440-41-7
No studies on immunotoxicity of Be metal are available. A total of two publications are relevant for this endpoint. Both publications (one abstract and one peer-reviewed) reflect the same experimental study.
The study by Haley (1992 and 1994) demonstrated an increase in numbers
of lymphocytes from lung lobe of cynomolgus monkeys exposed to Be metal
by intrabronchiolar instillation. An equivalent response was not seen in
animals exposed to BeO. There was also a marked increase in severity of
pulmonary lesions in animals exposed to Be metal relative to BeO.
This study demonstrates an immune response of Be that is primarily
restricted to the metal and seen to a much lesser extent with BeO. The
response is significant, particularly early following exposure but drops
off and is equal to control at the end of the study. Considering the
animal model used and the degree of response, the effect may be relevant
to humans. It is not known whether the exposure levels investigated in
this study is relevant for a human exposure scenario.
The studies are not appropriate for classification purposes.
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