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EC number: 231-150-7
CAS number: 7440-41-7
Table 1: Dissolution at neutral pH
Gamble's (pH 7.1)
Concentration of beryllium in the supernatant [mg/l]
% beryllium dissolved of theoretically available for dissolution
BeO Ceramic Powder
Be Metal Powder
CuBe Alloy Metallic Powder
Table 2: Dissolution at acidic pH
ALF (pH 4.5)
The dissolution behaviour (amount and kinetics) of different beryllium
compounds in artificial lung fluids was investigated. The dissolution
behaviour is considered to have significant influence on toxicokinetics
of the individual compounds and the read-across possibilities with
regards to toxicological properties of the beryllium compounds. The
compounds (beryllium metal, copper-beryllium alloy, beryllium oxide
ceramic and beryllium chloride) were grind to fine powders and loaded at
the same loading rate into artificial lung fluids at either neutral pH
(simulating the normal lung millieu) or at acidic pH (simulating a
lysosomal environment). The concentration of dissolved beryllium in the
samples (after removal of particulate matter by centrifugation) was
determined by atomic absorption spectrometry at day 1, day 7, day 14 and
day 28 after start of incubation.
For all compounds, solubility at acidic pH was higher than at neutral
pH. Solubility was beryllium chloride >> copper-beryllium alloy >
beryllium metal >> beryllium oxide ceramic. For all compounds, the
amount of dissolved beryllium stayed either constant or slowly increased
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