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EC number: 247-156-8
CAS number: 25640-78-2
Long-term toxicity to was examined in a pre-guideline study investigating the effect of (1-methylethyl)-1,1'-biphenyl on spawning, hatching, and fry survival of flagfish.
In a pre-OECD guideline study (Ozburn
et al 1980), effects of (1-methylethyl)-1,1'-biphenyl on spawning of
adult flagfish, hatching of exposed eggs (21 d exposure period each),
and survival of fry (10 d exposure) at five graduate concentrations was
examined. Effect thresholds were > 0.42 mg/L for spawning and hatching
impairment and 0.43 mg/L for survival of fry.
Data are partly in contrast to results
of short-term toxicity tests with flagfish. For fry, a 96 h LC50 of 0.28
mg/L was observed. It is not easy to explain that an even not exactly
defined threshold value (0.43 mg/L), corresponding to a long-term LC10
or NOEC, is higher than the short-term LC50. Together with the spawning
and hatching data, results of the long-term experiment can be taken as
evidence that an extended exposure period (21 or 10 d respectively) does
not severely enhance the adverse effects of isopropylbiphenyl to
The lowest value observed (0.43 mg/L)
is taken with due
caution as key value to characterise the long-term toxicity of
(1-methylethyl)-1,1'-biphenal to fish.
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