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EC number: 247-156-8
CAS number: 25640-78-2
In an early pre-OECD guideline study, LC50 for both adult fish and fry of flagfish have been determined. With the supporting substance 4-ethylbiphenyl, LC50 was determined for ricefish in a study according to OECD TG 203. The lower of both values is used as key value.
For the substance
(1-methylethyl)-1,1'-biphenyl (monoisopropylbiphenyl - MIPB), one study
on short-term toxicity to fish was identified (Ozburn et al 1980). The
procedure applied is based on an early US EPA guideline (Methods for
Acute Toxicity Tests with Fish, Macroinvertebrates, and Amphibians,
1975, EPA-660/3-75-009). Test type was a flow-through system. The study
includes a variety of endpoints and reporting is very limited.
Reliability of data is difficult to assess. Data are used in a Weight of
For the supporting substance
4-ethybiphenyl, data are available from the National Institute of
Technology and Evaluation of Japan (NITE) (CHRIP/NITE 1999). Results are
reported in databases of NITE without any direct details on methods or
measured data, although the general test methods can be found separately
in a methodological inventory. Furthermore, the methods are conform to
the respective OECD test guidelines. As data of NITE have a high
reputation of being robust, they are accepted as being reliable and
therefore are used for assessment. They are included in the Weight of
The following LC50 values have been
For the endpoint short-term toxicity
to fish, results with adult fish will be considered. Results of Ozburn
and CHRIP/NITE are close together. The result of CHRIP/NITE is taken as
key value as it is lower than the value of Ozburn and as the result of
Ozburn is not definite (> 0.75 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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