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EC number: 247-156-8
CAS number: 25640-78-2
High dose (not explicitely specified
but probably above 200 mg/kg bw/day) gave rise to nephrotoxicity, the
formation of renal lesions, and the presence of small calculi in the
renal pelvis and bladder. Histologically, interstitial nephritis and
papillary atrophy, oedema, degeneration and necroses were detected.
The renal pelvis, ureters and bladder
contained concretions that ranged from amorphous chalky material in the
pelvis of some animals to bladder stones in others. From collected
calculi which were resistant to enzymatic hydrolysis but not to 6 M HCl, the
biphenyl derivative of methylglycolic acid could be isolated, a
metabolite of isopropylbiphenyl. Its calcium salt is insufficiently
soluble to be readily excreted into the urine. It tends to become
sequestered in a crystalline state in the renal tubules over time
thereby producing renal toxicity. Renal toxicity of isopropylbiphenyl
may especially be evident in species which predominantly form 2-biphenyl methylglycolic
acid (2 -biphenyl lactic acid) as major metabolite.
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