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EC number: 247-156-8
CAS number: 25640-78-2
BCF values for (1-methylethyl)-1,1'-biphenyl were determined in a pre-guideline study using a method similar to OECD TG 305 E. For the two concentrations applied very diverging factors were determined. BCF value of the supporting substance 4-ethylbiphenyl and values calculated for comparison with seven different methods were with one exception below 2000.
BCF values for
(1-methylethyl)-1,1'-biphenyl were determined in a pre-guideline study
similar to OECD TG 305 E based on uptake and depuration rate constants
(Ozburn et al 1980). Documentation is limited. Individual fish
concentration data for the different time points of the study are not
reported as well as BCF values directly calculated from this data. BCF
values were obtained employing the calculation program BIOFAC. It uses
the fish concentration data of the uptake and the depuration phase to
calculate respective rate constants. BCF is received as the ratio of
uptake and depuration rate. BCF values calculated were
low concentration test group (3.5
high concentration test group (24.1
Both BCF values are remarkably
different. The difference is much more pronounced than is normal for
other substances similar to isopropylbiphenyl. In addition, compared to
BCF of substances with similar molecular structure, the BCF of the high
exposure group appears extremely high.
In order to assess the solidity of the
measured BCF values, two approaches were taken.
For the supporting substance
4-ethylbiphenyl, a measured value is reported in the literature
(Dimitrov, 2005). This value is quoted to be 667. 4-Ethylbiphenyl is
used with this value in the training sets of several QSAR models for
predicting BCF values. This value is considered as characterising the
range of the isopropylbiphenyl BCF. Justification for use of
4-ethylbiphenyl as supporting substance is given in the Section to
In a second step, BCF were estimated
for (1-methylethyl)-1,1'-biphenyl using various calculation/QSAR
methods. Methods/methodologies and results are displayed in the
US EPA EPI Suite
US EPA T.E.S.T.
regression based on log Kow
It is obvious, that none of the BCF
estimates is close to the value of 10,790 obtained for the high exposure
group of Ozburn. Except one value (3,471 - Arnot-Gobas), all other
values fall in the range below 2000.
Compared to the BCF of 4-ethylbiphenyl
as well as in comparison with the estimated BCF values of
isopropylbiphenyl, the measured BCF of 2,896 for
(1-methylethyl)-1,1'-biphenyl resulting from the low exposure group of
Ozburn appears already high but is considered yet to be realistic. This
value is taken as BCF of (1-methylethyl)-1,1'-biphenyl for further use
in the chemical safety assessment.
The BCF value for the high exposure
group of Ozburn is out of bounds by comparison to the data compiled to
evaluate the BCF value of isopropylbiphenyl. It is considered as outlier
and is disregarded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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