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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
The data source is considered reliable, altough no details on the measurement method are given.
Reason / purpose for cross-reference:
reference to same study
Principles of method if other than guideline:
not reported
GLP compliance:
not specified
Type of method:
other: not reported
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
2.47

The partition coefficients Oil/Air (log K) and water/air (log D) were also reported:

log K = 2.58

log D = -0.39

Conclusions:
According to the data source, the log Kow of HCFC 122a is 2.47.
Executive summary:

The objective of the reported reference was to study the toxicity of refrigerants HFCF 122a and HCFC 132 and to characterize their biological action in order to validate the approximate safe level of these compounds in the air of working area, ambient air, and water. In this study both a review of the available toxicological data on similar chemical compounds and acute and subacute toxicological tests on HFCF 122a and HCFC 132 were made.

A summary of the chemical and physical properties of the two substances was also included in the report, indicating a log Kow of 2.47 for HFCF 122a. Under the study the value was used for the calculation of the estimated median lethal dose in case of oral administration and the estimatedmedian lethal concentration in air.

The partition coefficients Oil/Air (log K) and water/air (log D) were also reported:

log K = 2.58

log D = -0.39

Description of key information

The Log Kow of HCFC 122a is 2.47.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.47

Additional information

A reliable reference is reported, indicating a log Kow = 2.47 for HCFC 122a.

The same data source also reports the partition coefficients Oil/Air (log K) and water/air (log D):

log K = 2.58

log D = -0.39