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EC number: 940-543-9
CAS number: 354-15-4
The objective of the reported study was to investigate
the toxicity of HFCF 122a and HCFC 132 and to characterize their
biological action in order to validate the approximate safe level of
these compounds in the air of working area, ambient air, and water. In
this study both a review of the available toxicological data on similar
chemical compounds was made and toxicological tests on HFCF 122a and
HCFC 132 were performed, including studies of skin absorption and acute
toxicity by oral and inhalation routes.
Information on the acute toxicity of HCFC 122a by dermal
exposure can be obtained from the study of skin absorption: under this
test, in a first stage of the experiment, the toxicity of HCFC 122a was
studied after application of the substances on the skin of the tails of
the white mice; contact time was 2 hours after which the tails were
washed with soap and water and the animals were observed for 14 days.
Since single exposure to the substances did not cause
symptoms of intoxication and death of animals the experiments with
repeated applications of HCFC 122a for 12 days were included. In this
phase HCFC 122a was applied to the section of rat skin sized 2 x 2 cm,
and the application time was 4 hours. In order to prevent evaporation of
the substances from the skin surface, the studied section of skin was
The functional state of the experimental animals, used to
determine if absorption occurred, was assessed based on some
physiological parameters: orientation response and summation-threshold
value (STV), the latter as index of adverse effect on the nervous
of summation of subthreshold pulses consists of recording of threshold
stress causing the motor response. According to the authors it has a
sufficiently high sensitivity for the detection of early changes in the
condition of the nervous system.
These physiological parameters were chosen basing on the
results of previous toxicological studies, which showed that the most
evident signs of toxicity HCFC 122a and HCFC 132 are adverse effects on
the nervous system.
Study showed that repeated application of HCFC 122a to
the skin did not lead to changes in appearance and behaviour of animals
and changes in functional parameters, indicating the absence of
expressed skin-absorption properties. Basing on the results, it can be
concluded that HCFC 122a does not posses potential toxicity following
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