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EC number: 940-543-9
CAS number: 354-15-4
The objective of the reported study was to investigate
the toxicity of HFCF 122a and HCFC 132 and to characterize their
biological action in order to validate the approximate safe level of
these compounds in the air of working area, ambient air, and water. In
this study both a review of the available toxicological data on similar
chemical compounds was made and toxicological tests on HFCF 122a and
HCFC 132 were performed.
The acute toxicity levels of the HCFC 122a were both
calculated and experimentally determined.
In order to obtain approximate data on the acute
toxicity of the HCFC 122a and HCFC 132, the following equation, derived
basing on experimental data on similar compounds, was applied:
LD50(mmol/kg) = 1.25 – 1.54 · tb· 10-2+
0.63 · log Pow
tb= boiling point
Pow = partition coefficient octanol/water
The calculated value of LD50for HCFC
122a is reported to be 8680 mg/kg b.w.
Following the calculation of the approximated LD50,
experimental studies of oral acute toxicity were conducted on white mice
and rats at dose from 3 to 15 g/kg.
During the acute experiment dynamic monitoring of
the clinical sign was carried out and the weight of animals was measured.
Results show that HCFC 122a is a low-toxic
compound, since the experimental results were very closed to the
predicted toxicity parameters.
signs in animals predominantly consisted of symptoms of nervous system
damage. Acute poisoning within the first hours was accompanied by
excitation of animals, followed by depression, motor retardation,
shortness of breath, muscle atonia. Death of laboratory animals was
observed within the first 1-3 days of observations. No
species-sensitivity was observed. HCFC
122a and HCFC 132 did not exhibit cumulative properties.
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