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EC number: 940-543-9
CAS number: 354-15-4
The objective of the research was to study the toxicity of refrigerants
HFCF 122a and HCFC 132 and to characterize their biological action in
order to validate the approximate safe level of these compounds in the
air of working area, ambient air, and water. In this study both a review
of the available toxicological data on similar chemical compounds was
made and toxicological tests on HFCF 122a and HCFC 132 were performed,
including studies of skin-absorption, eye irritating and skin
To identify the substance action on conjunctiva, the test
solutions of HCFC 122a and HCFC 132
were introduced into the conjunctival sac of rabbit eyes; besides,
local action of the substances was studied by Draize method.
Two drops of the substances were introducted into the conjunctival
sac of the rabbits. Changes were registered after 1, 24 and 72 hours,
and 7 days. The degree of damage to the mucous membranes of the eyes
caused by these compounds was assessed qualitatively based on changes in
the cornea, iris and conjunctiva.
Studies showed that immediately after the application of
refrigerants, the animals displayed sharp excitement. After 1 hour, the
palpebral fissure completely closed, diffuse corneal opacity developed,
conjunctival hyperemia and inflammatory edema of the eyelids was
observed. After 24 and 72 hours, the severity of the described processes
decreased, and a week later the changes almost disappeared; HFCF
122a caused more severe irritation than HCFC 132.
The study authors established that the test compounds exhibit
slight irritating effect on the mucous membranes of the eyes, wherein
these properties are more pronounced in HFCF 122a.
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