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EC number: 260-135-8
CAS number: 56375-79-2
In a GLP
compliant bacterial mutagenicity test, performed according to OECD TG
471 and 472, 4Salmonella typhimurium strains (TA 1535, TA 1537,
TA 98, and TA 100) and E. coli strain WP2 uvr A were used to test
the mutagenic potential of tributylmethylammoniummethylsulfate both with
and without metabolic activation. One standard plate test and one
preincubation test were performed at test concentrations of 0; 20; 100;
500; 2500 and 5000 µg/plate. Three plates per experiment per
concentration or control were used. No precipitation of the test
substance was found. A slight decrease in the number of revertants was
occasionally observed in the standard plate test. In the preincubation
assay bacteriotoxicity (reduced background growth, decrease in the
number of revertants) was observed using the Salmonella strains
depending on the test conditions from about 2500 µg/plate onward. There
was no increase in the number of revertants in any of theS.
typhimuriumorE. colitester strains at any dose, neither in
the standard plate test nor in the preincubation test, with or without
metabolic activation. It was therefore concluded that the test substance
is not mutagenic under these experimental conditions.
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