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EC number: 260-135-8
CAS number: 56375-79-2
an acute oral toxicity study performed with the substance according to
OECD TG 423, doses of 2000 and 300 mg/kg bw were administered by gavage
to three test groups of three fasted Wistar rats each (2000 mg/kg bw in
3 females and 300 mg/kg bw in 6 females). Mortality was observed in two
animals of the 2000 mg/kg bw test group. As substance-related clinical
signs poor general state, dyspnea, piloerection, ataxia, cowering
position, abdominal position and clonic convulsions were observed at
this dose level. Macroscopic pathological findings in the two animals
that died were dark red discoloration of the liver, bleedings into the
glandular stomach and red discoloration of the small intestine. No
mortality occurred at the 300 mg/kg bw dose level. As test-item related
clinical signs impaired general state, piloerection and reduced
defecation were reported. There were no macroscopic pathological
findings in the surviving animals sacrificed at the end of the
observation period. The mean body weight of the surviving animals
increased within the normal range throughout the study period with two
exceptions in the second 300 mg/kg test group. The mean body weights of
these animals increased in a normal range during the first week but did
not adequately increase during the second week. This effect is observed
at times in the rat strain used, because in the required age range the
female animals have already reached the phase of slow growth. Based on
these results the acute oral LD50was calculated to be LD50,
oral, rat > 300 < 2000 mg/kg bw.
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