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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
for read across substance
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two long term toxicity study of aquatic invertebrate for the test chemical :
1) The long term reproduction toxicity test was performed for test material. Test conducted in accordance with the OECD Guideline 211 (Daphnia magna Reproduction Test).
2) Study was conducted to access the effect of test chemical on the growth of aquatic invertebrates by providing the exposure rate of 21days. Test conducted in accordance with the OECD Guideline 211 (Daphnia magna Reproduction Test).
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material (IUPAC name): Tributylmethylammonium chloride
- Common name: Methy tributyl ammonium chloride (MTBAC)
- Molecular formula: C13H30ClN
- Molecular weight: 235.84 g/mol
- Smiles : [N+](CCCC)(CCCC)(CCCC)C.[ClH-]
- InChI : 1S/C13H30N.ClH/c1-5-8-11-14(4,12-9-6-2)13-10-7-3;/h5-13H2,1-4H3;1H/q+1;/p-1
- Substance Type: Organic
- Physical State: Liquid
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: 1) Daphnia magna 2) other invertebrate
Details on test organisms:
1) - Common name: Water flea
-Age : <24 h
-Food: fed daily during 21 days

2)
Test type:
static
Water media type:
other: growth media
Total exposure duration:
21 d
Test temperature:
1)25±1°C
Details on test conditions:
1) - The medium were changed every 1 or 2 days , neonatal were counted every day.
- The total number of fleas born over 21 days in the test fluid of each concentration and the total number born in the control group were statistically processed to determine .
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.125 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.98 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
reproduction
Conclusions:
The test chemical Tributylmethylammonium chloride is likely to be toxic to aquatic invertebrate for long term study atleast in the cocentarion range of 0.98 - 0.125 mg/l
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the long term toxicity of aquatic invertebrate of the test chemical Tributylmethylammonium chloride ( 56375-79-2).The studies are as mentioned below:

1) Long term toxicity reproductive test was performed as per OECD guideline .Daphnia magna less then 24h old were used at the initiation of the test . They were exposed to various concentrations The medium were changed every 1 or 2 days , neonatal were counted every day.The total number of fleas born over 21 days in the test fluid of each concentration and the total number born in the control group were statistically processed to determine . The long term toxicity reproduction test was performed for test material on Daphnia magna for 21 days , the NOEC was observed to be 0.125 mg/l.On the basis of above effect concentration it can be considered that test material has chronic effects on aquatic invertebrate and can be classified as aquatic chronic 2 as per CLP criteria.

2)Study was conducted to access the effect of test chemical on the growth of aquatic invertebrates by providing the exposure rate of 21days. Test conducted in accordance with the OECD Guideline 211 (Daphnia magna Reproduction Test). Study was conducted to access the effect of test chemical on the growth of aquatic invertebrates by providing the exposure rate of 21days. Test conducted in accordance with the OECD Guideline 211 (Daphnia magna Reproduction Test). Based on the readily biodegradability of test chemical and NOEC, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.

Thus, based on the above summarized studies,Tributylmethylammonium chlorideand it’s structurally and functionally similar read across substance, it can be concluded that effect concentration value is in the range of 0.98 to 0.125 mg/L. Thus, comparing this value with the criteria of CLP regulation,Tributylmethylammonium chloridecan be classified as aquatic chronic 2 for long term toxicity for aquatic invertebrate.

Description of key information

Long term toxicity to aquatic invertebrate:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the long term toxicity of aquatic invertebrate of the test chemicalTributylmethylammonium chloride(56375-79-2).The studies are as mentioned below:

1) Long term toxicity reproductive test was performed as per OECD guideline .Daphnia magna less then 24h old were used at the initiation of the test . They were exposed to various concentrations The medium were changed every 1 or 2 days , neonatal were counted every day.The total number of fleas born over 21 days in the test fluid of each concentration and the total number born in the control group were statistically processed to determine . The long term toxicity reproduction test was performed for test material on Daphnia magna for 21 days , the NOEC was observed to be 0.125 mg/l.On the basis of above effect concentration it can be considered that test material has chronic effects on aquatic invertebrate and can be classified as aquatic chronic 2 as per CLP criteria.

2)Study was conducted to access the effect of test chemical on the growth of aquatic invertebrates by providing the exposure rate of 21days. Test conducted in accordance with the OECD Guideline 211 (Daphnia magna Reproduction Test). Study was conducted to access the effect of test chemical on the growth of aquatic invertebrates by providing the exposure rate of 21days. Test conducted in accordance with the OECD Guideline 211 (Daphnia magna Reproduction Test). Based on the readily biodegradability of test chemical and NOEC, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.

Thus, based on the above summarized studies,Tributylmethylammonium chlorideand it’s structurally and functionally similar read across substance, it can be concluded that effect concentration value is in the range of 0.98 to 0.125 mg/L. Thus, comparing this value with the criteria of CLP regulation,Tributylmethylammonium chloridecan be classified as aquatic chronic 2 for long term toxicity for aquatic invertebrate.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.125 mg/L

Additional information

Long term toxicity to aquatic invertebrate:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the long term toxicity of aquatic invertebrate of the test chemicalTributylmethylammonium chloride(56375-79-2).The studies are as mentioned below:

1) Long term toxicity reproductive test was performed as per OECD guideline .Daphnia magna less then 24h old were used at the initiation of the test . They were exposed to various concentrations The medium were changed every 1 or 2 days , neonatal were counted every day.The total number of fleas born over 21 days in the test fluid of each concentration and the total number born in the control group were statistically processed to determine . The long term toxicity reproduction test was performed for test material on Daphnia magna for 21 days , the NOEC was observed to be 0.125 mg/l.On the basis of above effect concentration it can be considered that test material has chronic effects on aquatic invertebrate and can be classified as aquatic chronic 2 as per CLP criteria.

2)Study was conducted to access the effect of test chemical on the growth of aquatic invertebrates by providing the exposure rate of 21days. Test conducted in accordance with the OECD Guideline 211 (Daphnia magna Reproduction Test). Study was conducted to access the effect of test chemical on the growth of aquatic invertebrates by providing the exposure rate of 21days. Test conducted in accordance with the OECD Guideline 211 (Daphnia magna Reproduction Test). Based on the readily biodegradability of test chemical and NOEC, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.

Thus, based on the above summarized studies,Tributylmethylammonium chlorideand it’s structurally and functionally similar read across substance, it can be concluded that effect concentration value is in the range of 0.98 to 0.125 mg/L. Thus, comparing this value with the criteria of CLP regulation,Tributylmethylammonium chloridecan be classified as aquatic chronic 2 for long term toxicity for aquatic invertebrate.