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EC number: 801-709-5
CAS number: 53146-45-5
dermal irritation/corrosion study:
from severe erythema (beef redness) to eschar formation preventing grading
of erythema with slight edema (score:4/2) noted
immediately after patch
became severe erythema (beef redness) to eschar
formation preventing grading of erythema with severe edema (score:4/4).
and scars noted from the epidermis to the dermis.
In accordance with the OECD guidance document (No. 404), an acute
dermal-irritation potential of 1-butanol, reaction products with
2-[(2-propen-1-yloxy) methyl] oxirane was examined in the Yoshimi
Laboratories study (No. 1323). 0.5 mL of the application material
impregnated into a 2.5x2.5-cm piece of lint cloth was directly applied
to the application site, and the cloth was fixed with
adhesive stretch bandage. This semi-occlusive application was kept for 4
hours, and skin reaction was evaluated immediately after and 1, 24, and
48 hours after patch removal, pursuant to the table for grading of skin
reactions in the guideline.
As results, reactions from severe erythema (beef redness) to eschar
formation preventing grading of erythema with slight edema were noted
from immediately after patch removal.
Subsequently necroses and scars were noted from the epidermis to the
dermis, indicating a corrosive effect.
Thus no further experiment was performed.
Regarding the GHS classification, the test substance is classified as
Category 1 for its corrosive effect.
No abnormality was noted in general condition, and body weight showed an
increase during the observation period.
From the results described in the Acute Dermal-Irritation study in rats
it has been concluded that the test substance is corrosive and
classified as Category 1 in the GHS classification.
The eye irritation study need not be conducted because the available
information indicates that the criteria are met for classification as
corrosive to the skin or irritating to eyes.
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