Registration Dossier
Registration Dossier
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EC number: 202-716-0 | CAS number: 98-95-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Treatment of 2 white rabbits (New Zealand) on the inner side of the ear for 24 hours under occlusive conditions; dose: .5 ml. Observation period: 7 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrobenzene
- EC Number:
- 202-716-0
- EC Name:
- Nitrobenzene
- Cas Number:
- 98-95-3
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 h
- Observation period:
- 24h, 48h and 7 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: innder side of the ear
- Type of wrap if used: plaster (no further details)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The test side was washed with water and soap/vegetable oil.
- Time after start of exposure: 24 h
Results and discussion
In vivo
Results
- Irritation parameter:
- other: not irritant
- Basis:
- animal: rabit
- Time point:
- other: 7 days
- Score:
- 0
Any other information on results incl. tables
No reaction was observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
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