Registration Dossier
Registration Dossier
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EC number: 202-716-0 | CAS number: 98-95-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Excretion of p-Nitrophenol and p-Aminophenol in the urine of a patient exposed to nitrobenzene.
- Author:
- Ikeda, M. and Kitta, A.
- Year:
- 1 964
- Bibliographic source:
- Brit. J. Industr. Med. 21, 210-213
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Five adult Wistar rats were exposed to nitrobenzene vapour (0.13 mg/L) for 8 hours. Urinary levels of p-nitrophenol and p-aminophenol were determined using the method of Brodie and Axelrod (1948) after 24, 48 and 72 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- Nitrobenzene
- EC Number:
- 202-716-0
- EC Name:
- Nitrobenzene
- Cas Number:
- 98-95-3
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- single treatment for 8 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.13 mg/L (25 ppm)
- No. of animals per sex per dose / concentration:
- 5
- Control animals:
- no
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The metabolites p-nitrophenol and p-aminophenol of nitrobenzene were identified and quantified.
Any other information on results incl. tables
Urinary levels of p-nitrophenol (p-aminophenol) (µmoles/day and rat) were ca. 1800 (1200) after 24 hours, ca. 500 (both) after 48 hours and 0 (both) after 72 hours.
Applicant's summary and conclusion
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