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EC number: 202-716-0
CAS number: 98-95-3
Repeated inhalation of nitrobenzene
(intended dose: 25 mg/d; mean daily doses were 18.8, 18.2, 24.7 and 19.5
mg/d) for six hours daily, four successive days or for six hours daily
for 6 days intermitted by one day and followed by a six hour exposure
for a further day, vapour concentration 5 to 30 μg /l). The excretion of
p-nitrophenol increased in the first few days and became fairly steady
after the third day. Approximately 16% of the quantity of nitrobenzene
inhaled daily was excreted as p-nitrophenol. p-Aminophenol, the presence
of which was analyzed for in only one person who was exposed for four
days, was not detected (limit of colorimetric detection method was 10
μg/ml). From this study, the authors conclude that nitrobenzene vapour
is absorbed with 80% efficiency through the lungs (details were not
The absorption of nitrobenzene after 6 h
exposures of dressed and naked humans to nitrobenzene vapour (inhalatory
exposure could be excluded by the methodology used) was also
investigated. The author calculated that approximately half as much
nitrobenzene vapour was absorbed through the skin as through the lungs
when volunteers were exposed to 5 – 30 mg/m3 nitrobenzene. Vapour
absorption through the skin was proportional to the concentration of
nitrobenzene in the air. Normal working clothes reduced this absorption
by 20-30%. In high humidity, skin absorption of vapour was significantly
It is stated that if a worker was exposed
all day at a threshold level value of 1 ppm, approximately 25 mg of
nitrobenzene would be absorbed, of which about one-third would be by
skin absorption, the remainder by inhalation.
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