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EC number: 232-565-6
CAS number: 9000-90-2
The study was carried
out according to OECD guideline no. 405. Three rabbits were treated as
follows: One rabbit was treated first and two more aprox. one hour
later. An amount of 0.1 mL of the undiluted test substance was instilled
in the conjunctival cul-de-sac of one of the eyes of the rabbit. After
administration, the upper and the lower eye lid were carefully closed
and subsequently held together for at least one second before releasing
to prevent loss of material. The other eye remained untreated and served
as a control. The reactions of the eyes were judged at 1 h, 24 h, 48 h
and 72 h after treatment.
The only effects seen
were ocular discharge (score 1) in one rabbit at the 1 hour reading, and
slight redness with or without slight swelling of the conjunctivae
(score 1) in all rabbits at the examination at 1 hour and 24 hours after
exposure. However, these slight effects were cleared completely at the
following observations 48 and 72 hours after treatment. According to the
Globally Harmonised System of Classification and labelling of Chemicals
(GHS, UN/ECE 2003) alpha-amylase should not be classified as eye
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