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EC number: 232-565-6
CAS number: 9000-90-2
A study was performed to determine the partition coefficient of the test
substance, Glucoamylase, according to EEC Method A8 and OECD Method 107.
The study was conducted to comply with the requirements of European
Council Directive for 91/414/EEC (Annex II) as amended by European
Commission Directive 94/37/EC and amended by Commission Regulation (EU)
No. 544/2011 Implementing Regulation (EC) Nov 1107/2009 of the European
Parliament and of the Council as regards the data requirements for
The octanol/water partition coefficient of Glucoamylase was found to be
< 0.05 (log10 Pow = < -1.3).
All enzymes are built up of the same amino acids and only order
differs and it is thus concluded that alpha-amylase also has a logPow
value in the narrow range from < 0.05 (log10 Pow = < -1.3).
Because all enzymes are built up of the combination of the same 20
common amino acids, the physical and chemical characteristics are very
similar for different enzymes, and hence, read-across from other enzymes
should be fully applicable. The logPow value of the present target
substance has not been determined but other enzymes have been analysed
and the LogPow from literature studies was found to be between -3.1 to
In addition, the octanol-water partition coefficient (logPow) for
glucoamylase was measured <= -1.3 at 20°C.
Due to the similar nature of enzymes, this value can also be
extrapolated to alpha-amylase.
- Basketter D, Berg N, Broekhuizen C, Fieldsend M, Kirkwood S, Kluin C,
Mathieu S, Rodriguez C (2012a). Enzymes in Cleaning Products: An
Overview of Toxicological Properties and Risk Assessment/Management.
Regul.Toxicol. Pharmacol., 64(1):117-123.
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