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EC number: 201-553-2
CAS number: 84-69-5
In an in vitro assay, (OECD 433) treatment of skin tissues with diisobutyl phthalate was not corrosive. The test was conducted according to standard guidelines and GLP and met the validity criteria. In a non-standard irritation assay using an injection technique, diisobutyl phthalate did not induce any irritation in mice exposed between one and 10 days to neat material. Diisobutyl phthalate was not irritating to rabbit eye. Information available for other phthalate diesters confirms that they are not irritating to skin or eye.
The two available studies for diisobutyl
phthalate on skin show that it is not an irritant material. Similarly no
irritation was in a rabbit eye test. This lack of irritation potential
is consistent with results obtained for other phthalate diesters and
summarised in EU risk assessment reports e.g. ECHA 2003a,c ; 2007; 2008 .
European Union Risk Assessment Report: dibutyl phthalate, volume 29.
Office for Official Publications of the European Communities, Luxembourg.
European Union Risk Assessment Report 1,2-BENZENEDICARBOXYLIC ACID,
DI-C8-10-BRANCHED ALKYL ESTERS, C9-RICH AND DI-“ISONONYL” PHTHALATE
(DINP) CAS Nos: 68515-48-0 and 28553-12-0 EINECS Nos: 271-090-9 and
249-079-5 RISK ASSESSMENT Volume
35 Office for Official Publications of the European Communities,
European Union Risk Assessment Report BENZYL BUTYL PHTHALATE (BBP) CAS
No: 85-68-7 EINECS No: 201-622-7 Volume
76 Office for
Official Publications of the European Communities, Luxembourg.
European Union Risk Assessment Report BIS(2-ETHYLHEXYL) PHTHALATE (DEHP)
CAS No: 117-81-7 EINECS No: 204-211-0 Volume 80 Office
for Official Publications of the European Communities, Luxembourg.
The available information, both direct and
indirect, on skin and eye show that DIBP does not require classification
for irritant properties to the skin and eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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