Registration Dossier
Registration Dossier
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EC number: 201-553-2 | CAS number: 84-69-5
Endpoint summary
Administrative data
Description of key information
In an in vitro assay, (OECD 433) treatment of skin tissues with diisobutyl phthalate was not corrosive. The test was conducted according to standard guidelines and GLP and met the validity criteria. In a non-standard irritation assay using an injection technique, diisobutyl phthalate did not induce any irritation in mice exposed between one and 10 days to neat material. Diisobutyl phthalate was not irritating to rabbit eye. Information available for other phthalate diesters confirms that they are not irritating to skin or eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The two available studies for diisobutyl phthalate on skin show that it is not an irritant material. Similarly no irritation was in a rabbit eye test. This lack of irritation potential is consistent with results obtained for other phthalate diesters and summarised in EU risk assessment reports e.g. ECHA 2003a,c ; 2007; 2008 .
EU (2003) European Union Risk Assessment Report: dibutyl phthalate, volume 29. Office for Official Publications of the European Communities, Luxembourg.
EU (2003c) European Union Risk Assessment Report 1,2-BENZENEDICARBOXYLIC ACID, DI-C8-10-BRANCHED ALKYL ESTERS, C9-RICH AND DI-“ISONONYL” PHTHALATE (DINP) CAS Nos: 68515-48-0 and 28553-12-0 EINECS Nos: 271-090-9 and 249-079-5 RISK ASSESSMENT Volume 35 Office for Official Publications of the European Communities, Luxembourg.
EU (2007) European Union Risk Assessment Report BENZYL BUTYL PHTHALATE (BBP) CAS No: 85-68-7 EINECS No: 201-622-7 Volume 76 Office for Official Publications of the European Communities, Luxembourg.
EU (2008) European Union Risk Assessment Report BIS(2-ETHYLHEXYL) PHTHALATE (DEHP) CAS No: 117-81-7 EINECS No: 204-211-0 Volume 80 Office for Official Publications of the European Communities, Luxembourg.
Justification for classification or non-classification
The available information, both direct and indirect, on skin and eye show that DIBP does not require classification for irritant properties to the skin and eye.
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