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EC number: 201-553-2
CAS number: 84-69-5
Diisobutyl phthalate is not acutely toxic.
In two separate studies, both done to
pre-guideline methodologies, the oral LD50 of DIBP was found to be over
10 g per kilogram body weight, and between 16 and 28 g per kilogram
Dermal exposures also elicited minimal
toxicity - with 10ml per kilogram body weight applied to the backs of
guinea pigs with an occlusive dressing not giving rise to any
toxicological effects or deaths.
Two reports of the determination of an LD50
in the male mouse via intraperitoneal injection reported values of
approximately 4 g per kg bw.
There is no information on the inhalation
hazard of DIBP - however phthalate esters generally are of extremely low
toxicity by the inhalation route - as for all other routes.
Consequently, this particular endpoint is waived on the basis that any
potential exposures could not approach levels that are acutely toxic.
Typical values cited in reviews for inhalation toxicity of phthalate
esters are greater than 15 mg/l (DBP as cited in the official EU risk
assessment - EU 2003)
The available data together with supporting information for other
phthalate diesters indicates that DIBP does require classification for
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