Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1954
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1954
Report date:
1954

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Diisobutyl phthalate
EC Number:
201-553-2
EC Name:
Diisobutyl phthalate
Cas Number:
84-69-5
Molecular formula:
C16H22O4
IUPAC Name:
1,2-bis(2-methylpropyl) benzene-1,2-dicarboxylate

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Doses:
5 and 10 mL
No. of animals per sex per dose:
2 Guinea pigs were used
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD0
Effect level:
10 mL/kg bw
Based on:
test mat.
Mortality:
None by 14 days post exposure
Clinical signs:
other: No data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU