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EC number: 201-553-2
CAS number: 84-69-5
The data on DIBP are not extensive, but are
consistent with findings for other phthalate diesters (e.g. DBP, DEHP)
and indicate an
overall absence of genotoxic activity (EU
In two Salmonela assays (with or without
metabolic activation) DIBP returned a negative response.
One study reported effects in a non standard
commet assay but this is of unkown relevance given the non standard
nature of the
assay, the cell types examined and an
absence of historical data.
In 13 week mouse feeding study performed by
NTP with DBP (dose levels up to 20,000 ppm) analyses of peripheral blood
from males and females showed no increased
incidences of micronucleated normochromatic erythrocytes.
EU (2003) European Union Risk Assessment
Report: dibutyl phthalate, volume 29. Office for Official Publications
of the European
EU (2008) European Union Risk Assessment
Report: bis(2-ethylhexyl) phthalate (DEHP), volume 80. Office for
of the European Communities, Luxembourg.
The available data together with supporting
information for other phthalate diesters indicates that DIBP does
require classification for genotoxicity.
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