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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information


A single study (Geiger 1985) is available for the endpoint of short-term toxicity to fish. This reports that the 96hr LC50 of Diisobutyl phthalate to Fathead minnows (freshwater fish) was determined to be 0.90 mg/L. These data are adequate to fulfil this endpoint.

There are no experimental studies available for the long-term toxicity to fish endpoint for diisobutyl phthalate, however there is a study available on the close structural analogue dibutyl phthalate which provide a suitable read across. Rhodes (1995) reports a 99 -day flow through test with Onconrhychus mykiss. The most sensitive endpoint measured is growth, for which the NOEC is 0.10 mg dibutyl phthalate/L.


A single study (Linden 1979) is available for the short-term toxicity to aquatic invertebrates endpoint. It reports that the 96 h LC50 of diisobutyl phthalate to Nitocra spinipes is 3.0 mg/l. This result is adequate to fulfil this endpoint.

There are no available data for the corresponding long term toxicity. This endpoint has been waived.


A single study for this endpoint (Harlan 2010) is available. This reports a 72 hr EC50 of diisobutyl phthalate to the green alga Desmodesmus subspicatus, based on growth rate, of 1.7 mg/L. The corresponding NOEC is 0.35 mg/L.


In the toxicity control of a guideline biodegradation study with activated domestic sludge (Clarke, 2010) the 14 day biodegradation of sodium benzoate exposed together with the test item was 55%. ≥ 25 % degradation is considered to be an indication of a non-inhibitory substance according to OECD 301 guideline. Thus the test item concentration of 14.5 mg/L, is considered to be an applicable NOEC.