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EC number: 201-553-2
CAS number: 84-69-5
The subchronic oral toxicity of dibutyl
phthalate was investigated in groups of F344/N rats (n = 10/sex) fed
diets containing 0, 2500, 5000, 10000, 20000 or 40000 ppm DBP. This was
equivalent to approx. 0, 176, 359, 720, 1,540 or 2,964 mg/kg bw for
males and approx. 0, 178,356, 712, 1,413 or 2,943 mg/kg bw for females.
The overall NOAEL from this study was 2500 ppm DIB in the diet
(equivalent to 177 mg/kg bw/d, both sexes) based on alterations in
haematological, serum chemistry and organ weight values at 5000 ppm.
The NOAEL for effects on testis (degeneration of germinal epithelium)
was 5000 ppm (359 mg/kg bw/d). The NOAEL for peroxysome
prolifearation-related changes (increased PCoA activity) was 2500 ppm in
both sexes (177 mg/kg bw/d).
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