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EC number: 265-191-7
CAS number: 64742-88-7
A complex combination of hydrocarbons obtained from the distillation of crude oil or natural gasoline. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C9 through C12 and boiling in the range of approximately 140°C to 220°C (284°F to 428°F).
high dose male mice were lethargic shortly after dose administration and
on the following day. In the high dose males and females and the
mid-dose males there was a slight weight loss between the time
pretreatment body weights were measured and when the animals were
treated with colchicine on the following day.
The body weight changes are shown below:
% change (+ or -)
SCEs were counted in 50 second-division metaphase cells and these data
are summarized in the following table.
Range of mean SCEs/cell for Individual Animals
Average SCEs/cell per mouse (a)
4.68 - 5.84
5.28 - 7.36
6.76 - 10.46
6.98 - 8.26
5.68 - 7.58
6.8 - 9.84
5.72 - 7.66
6.56 - 12.3
6.68 - 9.28
7.28 - 8.54
36.6 - 44.18
18.34 - 31.64
(a) Mean ± standard deviation (Median SCEs/cell)
*P < 0.05
** P < 0.01 (Mann Whitney test)
was concluded that the negative and positive controls fulfilled the
requirements and that API 81-07 was positive in male mice.
In a mammalian cell
SCE assay, four hours after agar-coated BrdUrd pellet implantation the
mice were given hydrodesulfurised kerosine as a single i.p dose at doses
of either 400, 2000 or 4000 mg/kg in corn oil at a dose volume of 10
mL/kg (doses based a range finding study). A solvent control group
was given corn oil at a dose of 10 mL/kg. Two positive control groups
were used. One received cyclophosphamide i.p. at a dose of 10 mL/kg and
the other received API 81-15 (a carcinogenic heavy fuel oil component)
at a dose level of 4 g/kg, also at an injection rate of 10 mL/kg.
Positive control group
API 81 -15 induced a significant increase in SCEs/cell/mouse relative to
the vehicle control, as did the cyclophophamide. The results of the
assay indicate that under the conditions described in this report, the
test article hydrodesulfurised kerosine does induce a significant
increase in bone marrow SCEs in male B6C3F1 mice, but not in female
female mice responded positively to administration of both
cyclophosphamide (10 mg/kg) and a carcinogenic heavy fuel oil (4000
mg/kg) which were used as positive control. The doses of the test
article were rather high (400, 2000 and 4000 mg/kg) and the males in the
highest dose groups showed signs of toxicity (lethargy and weight loss)
on the day of the administration of the kerosine and the day after (when
they were sacrificed).
This study received a
Klimisch score of 1 and is classified as reliable without restriction
because it was carried out in a method equivalent/similar to OECD TG 479
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