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EC number: 265-191-7
CAS number: 64742-88-7
A complex combination of hydrocarbons obtained from the distillation of crude oil or natural gasoline. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C9 through C12 and boiling in the range of approximately 140°C to 220°C (284°F to 428°F).
In classical animal
assays for skin sensitisation such as the Magnusson-Kligman GPMT and the
Buehler assay, kerosines and jet fuels did not trigger a positive
In the key dermal
sensitisation study (Klimisch score=1; ARCO, 1992q), thermocracked
kerosine in mineral oil was tested on male young adult Pig/Hartley
guinea pigs using a modified Buehler technique. During the challenge
phase, a second exposure of a 1:4 dilution of thermocracked kerosine to
induced test animals did not yield higher response grades, severity, or
incidence than those associated with the naive challenge control group
exposed to thermocracked kerosine. During the challenge phase, exposure
of 0.2% DNCB to induction positive control animals elicited
significantly higher response grades, severity indices, and incidence
over the naive DNCB challenge control group. The vehicle irritation
control group was free of dermal irritation during the challenge phase.
Therefore, under the conditions of this study, thermocracked kerosine is
not considered a delayed contact sensitiser and DNCB induced an
appropriate positive response.
In supporting studies
(ARCO, 1992r; ARCO, 1992s; ARCO, 1992t; ARCO, 1992u; Kinkead et al.,
1992; ARCO, 1986l; ARCO, 1986m; ARCO, 1986n; API, 1985a), kerosines were
not found to be sensitisers to the skin of guinea pigs. In
some of the studies (ARCO, 1992u; ARCO, 1986l; ARCO, 1986m; ARCO,
to inherent irritative properties of the material, additional negative
controls (challenge controls) were added at the challenge phase of the
study. The irritation scores of the test material were compared to the
challenge controls and only scores in excess of these controls were
considered positive sensitisation responses.
on test data, there was no evidence of skin sensitisation; therefore,
kerosine is not classified for skin sensitisation according to EU
CLP Regulation (EC No. 1272/2008)
support that kerosines are not skin sensitisers (API, 1980a; API, 1984a;
Kanikkannan et al., 2000). This information is presented in the dossier.
This endpoint is not a
are not considered skin sensitisers based on the information presented
above. Therefore, kerosines do not meet the criteria for classification
as a dermal sensitiser under EU CLP Regulation (EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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