Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-292-6
CAS number: 4292-10-8
Intradermal injections containing Freund´s
complete adjuvant: elicited well-defined dermal irritation
Intradermal injection of 0.5 % v/v test item
in all test animals: temporary slight dermal irritation
Second stage (topical application) of 60 %
v/v test item:slight dermal reactions
Challenge (10 % v/v Test item):
After 24 h: slight erythema (1): 2 animals
Control animals: no reactions
All animals (test and control animals)
showed slight bandage reactions
In a dermal
sensitization study with Coco AAPB (commercial product) 20 male
Pirbright white guinea pig were tested using the MAXIMIZATION
TEST described by b. Magnusson
and A.M. Kligman (1970). The test method is similar to OECD Guideline
406 (Skin Sensitisation).
The analytical purity of the test item is
not stated in study report, according to producer information test
material has 30 % a.i., impurities relevant to sensitisation and
referred to a.i. are 8.3 % Alkylamidopropylamine and 33 -50 ppm DMPA
At the first scoring, 24 h after challenge,
2/15 showed a skin reaction score 1 (slight erythema (barely
perceptible)). The animals were free of erythema and edema at the second
(48 h) and the third (72 h) scoring. None of the five negative animals
showed up to and including the third scoring a positive skin reaction to
study, Coco AAPB (30 % a.i.) is
not a dermal sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again