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EC number: 224-292-6
CAS number: 4292-10-8
In a ready
biodegradation test (EU Method C.4-F, MITI test), C12 AAPB showed to be
biodegraded between 82% (based on ThOD) and 95% (based on COD) after 28
days. Based on these experimental results, C12 AAPB can be considered as
readily biodegradable and thus, to be not P and not vP.
Measured BCFs are not
available for the C8-18 derivates of AAPB. Still, these derivates fall
in the range of applicability of a scientifically valid (Q)SAR model:
BCFWIN. Therefore, BCFWIN v2.15 was used to calculate the BCF values for
the C8-C18 derivates of AAPB. The calculation yielded values in the
range between 3 (C8 fatty acid derivate) and 71 (C10 – C18 and C18
unsaturated fatty acid derivates). Based on these calculated BCFs, a low
potential for bioaccumulation is to be expected for AAPBs. This
conclusion especially applies to C12 AAPB and is further supported by a
log Kow value of 3.54 (≤ 4.5) estimated using the chemical properties
prediction software ACD/Labs v12 and the experimentally determined Koc
of C12 AAPB. Based on these (Q)SAR results, C12 AAPB can be considered
to be not B and not vB.
ecotoxicity data are not available for C12 AAPB. Still, an analogy can
be made with C8-18 AAPB for which such data are available and showed to
be in the range between 0.135 mg/L (Oncorhynchus mykiss: 28-day
NOEC) and 0.300 mg/L (Daphnia magna: 21-day NOEC), well above
0.01 mg/L. Besides,
the substance is not classified as carcinogenic (category 1 or 2),
mutagenic (category 1or 2), or toxic for reproduction (category 1, 2 or
3) according to Directive 67/548/EEC or carcinogenic (category 1A or
1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction
(category 1A, 1B or 2) according to Regulation EC No 1272/2008.
Moreover, there is no evidence that the substance exhibits chronic
toxicity, as identified by the classifications T, R48 or Xn, R48
according to Directive 67/548/EEC or specific target organ toxicity
after repeated exposure (STOT RE category 1 or 2) according to
Regulation EC No 1272/2008. Based on these results, C12 AAPB can be
considered to be not T.
Based on available
data, C12 AAPB is not P/vP (readily biodegradable), B/vB (calculated BCF
< 2000; estimated log Kow ≤ 4.5) and not T (NOEC ≥ 0.01 mg/L for
marine/freshwater organisms by analogy with C8-18 AAPB; not classified
as carcinogenic, mutagenic or toxic for reproduction). Consequently, C12
AAPB does not meet the PBT or vP/vB criteria according to Annex XIII of
the REACH Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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