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EC number: 224-292-6
CAS number: 4292-10-8
LD50 values reported by the study authors refer to the test substance as specified above (30 % a.i.): 7.45 (6.48 - 8.57) ml/kg after 14 days and 8.10 (6.81 - 9.64) ml/kg after 24 hours
Density of the substance: roughly 1 g/cm3.LD50 (14 day) referring to 100 % active substance: 2235 mg/kg bwLD50 (24 hours) referring to 100 % active substance: 2430 mg/kg bw
In an acute
oral toxicity study according to US Guideline Appraisal of the Safety of
Chemicals in Food, Drugs and Cosmetics, FDA, 1959, which is comparable
to the OECD guideline 401 (1981), 5 male and 5 female Wistar rats were
given a single oral dose of Coco AAPB (30 % a.i.) as delivered by the
sponsor at doses of 5.0, 6.3, 7.94, and 10.0 ml/kg bw. Animals were then
observed for 14 days.
6.3, 7.94, and 10.0 ml/kg bw 2/10, 2/10, 6/10, and 8/10 animals died,
respectively. Most animals died within 24 hours p.a.. Weight gains were
normal in all animals. Clinical signs at >= 5 mL/kg bw were decreased
motor activity, coordination disturbances, abnormal body posture,
piloerection, diarrhoea, skin/mucosa cyanosis and decreased body
temperature with dose response realtionship. At >= 7.94 mL/kg bw animals
showed prone position. Clinical signs were observed at 20 minutes, 1 h
and 3 h after application. Except of slight diarrhoea in one animal in
dose groups 6.3, 7.94 and 10 mL/kg bw, each, all symptoms were
reversible after 24 hours. 7 days after application, all surviving
animals were free of clinical symptoms. Gross pathology examination of
animals found dead revealed reddened gastric and intestinal mucosa.
Animals sacrificed at study termination 14 days p.a. had light reddened
LD50 Combined = 7.45 mL/kg bw after 14 d
LD50 Combined = 8.1 mL/kg bw after 24 h
determined refers to the test substance as delivered by the sponsor.
There is no information on content of active ingredient of the test
substance in the study report. However, according to producer
information tested Coco AAPB has 30% active ingredient. The density is
roughly 1 g/mL. Therefore the calculated oral LD50 combined referring to
100 % active substance = 2335 mg/kg bw after 14 d
is of low toxicity based on the LD50 in males and females.
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