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EC number: 224-292-6
CAS number: 4292-10-8
patients showed positive allergic reactions to CAPB (3.8%)
patients showed irritant reactions (slight erythema only) to CAPB (1.25%)
with positive reactions tested:
CAPB (30 % a.i.): 1 % aq. 30/30 (100 %)
3 -dimethylaminopropylamine 1 % aq. 30/30 (100 %)
cocamidoamine 0.05 % aq. 0/30
monochloracetic acid 0.1 % aq. 0/30
CAPB purer grade (30 % a.i.) 1 % aq. 16/30 (53.3 %)
Tego 103 G 1 % aq. 0/30
in the patients with irritant reactions, patch tests with all the above
substances were negative (no detailed data given). No allergic or
irritant reactions to DMPA were obtained in 50 healthy controls.
a dermal sensitization study with Coco AAPB (30 % a.i.) in water, 1200
patients with dermatitis of various types (study 1), and 30 patients out
of study 1 with positive reactions to Coco AAPB (study
2) were tested using the patch test method. Coco AAPB was
tested in commercial grade and purer grade, 3-dimethylaminopropylamine
(DMPA, 1 % aq.) was also tested.
study 1, 3.8 % (46/1200) of the patients showed allergic reactions and
1.25 % (15/1200) showed irritant reactions to Coco AAPB. Whereas, all
patients in study 2 showed positive reactions to Coco AAPB with high
grade of impurities
and DMPA. The positive reactions to Coco AAPB
were 10 and 53 %, respectively. The authors suggested that DMPA present
as impurity in the commercial Coco AAPB is responsible for Coco AAPB
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