Registration Dossier
Registration Dossier
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EC number: 285-597-8 | CAS number: 85117-47-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: No report on this study was provided to WRc, therefore this data has not been reviewed. All data provided in this study record was entered by the data owner.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- {CAS# 722503-68-6}
- IUPAC Name:
- {CAS# 722503-68-6}
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Peanut Oil
- Details on exposure:
- See study report attached
- Duration of treatment / exposure:
- Single Treatment/exposure
- Frequency of treatment:
- Single exposure (one-treatment)
- Post exposure period:
- 2 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
6 Males / 6 Females per dose level/ of 47.0, 94.0, and 188.0 mg/kg bw; Single IP treatment; 24 harvest/48 hour timepoint
Basis:
- No. of animals per sex per dose:
- 6 males/6 females per dose level/harvest point
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Cyclophosphamide (CAS 6055-19-2)
Examinations
- Tissues and cell types examined:
- Bone marrow polychromatic erythrocytes
- Details of tissue and slide preparation:
- See study report attached
- Evaluation criteria:
- See study report attached
- Statistics:
- See study report attached
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- See study report attached
Any other information on results incl. tables
See study report attached
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Not Clastogenic - Executive summary:
See study report attached
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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