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EC number: 285-597-8
CAS number: 85117-47-1
The substance has been assessed by exposure to guinea pigs and to
humans. In both guinea pig studies, the substance has been observed to
cause sensitisation by repeated insult. This observation is further
supported by the review of data conducted by a technical committee of
the WHO and included in this section.
The effects seen in guinea pigs would seem not, however, to be
consistent with the effects observed when the substance was exposed to
humans. Under the conditions of a repeated insult human volunteer test,
the substance demonstrated a low background incidence of results but at
levels that are considered to be not statistically significant and the
substance was considered not sensitising under the conditions of the
test. This observation is also supported by the review of data
conducted by a technical committe of the WHO and included in this
Based on the data available and the observations of the WHO technical
committee, it would seem likely that an interspecies difference exists
with regard to the sensitising potential of the registered substance
which might be due to guinea pigs being a more sensitive species to the
substance or the substance being less readily absorbed by human skin.
Migrated from Short description of key information:
The sensitisation potential of the substance has been assessed to humans and guinea pigs
Respiratory sensitisation has not been assessed.
Given that classification and labelling of chemicals is, by definition,
a mechanism for the communication of hazard to humans, it is considered
justifiable to assume a greater weight of relevence to data collected
from human exposure compared to the data collected from exposure to
guinea pigs. It is, therefore, considered justifiable to classify the
substance according to the data available from human data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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