Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 285-597-8 | CAS number: 85117-47-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The substance has been assessed by exposure to guinea pigs and to humans. In both guinea pig studies, the substance has been observed to cause sensitisation by repeated insult. This observation is further supported by the review of data conducted by a technical committee of the WHO and included in this section.
The effects seen in guinea pigs would seem not, however, to be consistent with the effects observed when the substance was exposed to humans. Under the conditions of a repeated insult human volunteer test, the substance demonstrated a low background incidence of results but at levels that are considered to be not statistically significant and the substance was considered not sensitising under the conditions of the test. This observation is also supported by the review of data conducted by a technical committe of the WHO and included in this section.
Based on the data available and the observations of the WHO technical committee, it would seem likely that an interspecies difference exists with regard to the sensitising potential of the registered substance which might be due to guinea pigs being a more sensitive species to the substance or the substance being less readily absorbed by human skin.
Migrated from Short description of key information:
The sensitisation potential of the substance has been assessed to humans and guinea pigs
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Migrated from Short description of key information:
Respiratory sensitisation has not been assessed.
Justification for classification or non-classification
Given that classification and labelling of chemicals is, by definition, a mechanism for the communication of hazard to humans, it is considered justifiable to assume a greater weight of relevence to data collected from human exposure compared to the data collected from exposure to guinea pigs. It is, therefore, considered justifiable to classify the substance according to the data available from human data.
Based on data available from human exposure, the substance is considered to be not sensitising.
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