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EC number: 285-597-8
CAS number: 85117-47-1
Irritant/corrosive response data for each animal at each observation
time up to removal of each animal from the test
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Average 24h, 48h, 72h
Average time (unit) for reversion
c. = completely reversible;= not completely reversible; n. = not
primary dermal irritation study ,
3 young adult New Zealand white rabbits were
dermally exposed to 0.5 ml of
sodium 4-icosylbenzenesulfonate for
Animals then were observed for 14 days.
Irritation was scored by the method of Draize.
this study, sodium 4-icosylbenzenesulfonate is not a
In a primary eye
irritation study 0.1 ml of sodium 4-icosylbenzenesulfonate was instilled
into the conjunctival sac of young adultwhite rabbits (3/sex). Animals
then were observed for 7 days. Irritation was scored by the method of
No eye irritation
was observed. In this study, sodium 4-icosylbenzenesulfonate is not an
All available skin irritation and eye irritation data available
demonstrate that the substance tested was not
irritating to skin or eyes.
Data are presented only using in vivo methods as these data were
available for the substance. In vitro data are
considered not justifiable scientifically or by expense as the data are
not likely to provide any additional
contribution to the conclusion available from the in vivo data.
Justification for selection of skin irritation / corrosion endpoint:
In a primary dermal irritation study , 3 young adult New Zealand white rabbits were dermally exposed to 0.5 ml of sodium 4-icosylbenzenesulfonate for 4 hours. Animals then were observed for 14 days. Irritation was scored by the method of Draize.
In this study, sodium 4-icosylbenzenesulfonate is not a dermal irritant.
Justification for selection of eye irritation endpoint:
Mean scores at 24, 48 and 72 hours for each animal for corneal opacity and iritis was 0 for all animals. Score for conjunctival rednes and oedema werer less than 2 in all of the animals. Therefore, this substance is not irritating to rabbit eyes.
Based on the data available for skin and eye irritation, exposure to the
substance gives rise to no adverse
reactions. The substance is, therefore, considered to be not irritating
to skin or eyes.
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