Registration Dossier
Registration Dossier
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EC number: 285-597-8 | CAS number: 85117-47-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: No report on this study was provided to WRc, therefore this data has not been reviewed. All data provided in this study record was entered by the data owner.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- {CAS# 722503-68-6}
- IUPAC Name:
- {CAS# 722503-68-6}
- Details on test material:
- See study report attached.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- See study report attached.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 mL instilled into one eye
- Duration of treatment / exposure:
- 6 animals treated unwashed and 3 treated and eyes washed for 1 minute starting 30 minutes after instillation.
- Observation period (in vivo):
- 72 hrs
- Number of animals or in vitro replicates:
- 9
- Details on study design:
- See study report attached.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 0.4
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 0.3
- Irritation parameter:
- other: Draize Score
- Basis:
- mean
- Time point:
- other: 24 hr
- Score:
- 4
- Irritant / corrosive response data:
- See study report attached.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- This material is not considered an eye irritant based on study data.
- Executive summary:
0.1 mL of {CAS# 722503-68-6} was instilled into one eye of each of nine rabbits (six with treated eyes unwashed and three with treated eyes washed for 1 minute starting 30 seconds after instillation). The test material produced only conjunctival irritation in unwashed eyes which cleared in all animals by 24 hrs. Eyes treated and washed produced only conjunctival irritation which cleared in all animals by 72 hrs.
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