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EC number: 292-429-7
CAS number: 90622-29-0
A pre-test screen with 3 animals/sex was conducted to
determine induction concentrations producing no more than moderate
irritation, and a maximum non-irritation challenge concentration. Based
on screen results, a 5% v/v solution of test substance in corn oil was
selected for intradermal injection, and 100% undiluted test substance
was selected for the topical application (induction and challenge).
A maximization test for topically applied test substances
was conducted on 30 short-haired male and female albino guinea pigs
using the methods of Magnusson and Kligman according to the OECD
Guideline of the Testing of Chemicals No. 406 "Skin Sensitisation",
adopted on 17th July 1992.
Test group animals (10/sex) received three pairs of
intradermal injections (adjuvant, a solution of test substance in corn
oil, and a 50:50 mixture of adjuvant and the test substance solution)
followed one week later by a single topical application of the undiluted
test substance. Ten additional animals (5/sex) served as a control
group. Control animals were treated at the same time periods and
locations but with the vehicle used in place of the test substance
solution. Two weeks after the topical application, the test animals were
challenged with a second topical application of the undiluted test
substance at a virgin test site. Control animals were also given a
topical application of undiluted test substance. The percentage of
animals exhibiting erythema with or without edema after the challenge
treatment was used to assign the test substance a sensitization potency
rating. Since none of the test animals exhibited scores greater than 0,
the test substance Alkenes, C11 -12, hydroformylation products, distn.
residues was given a sensitization potency rating of non-sensitizer
During the study, two test animals and one control animal
died; deaths were not considered related to substance administration.
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