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EC number: 292-429-7
CAS number: 90622-29-0
CAL 145 comprises alkenes C13-14 hydroformylation products with
read-across from the chemically-similar Alchisor CAL 123 as defined in
the `Read-Across Justification Document'. Where
environmental toxicity data exist for Alchisor CAL 123, these are
representative of the Alchisor CAL 145 substance. The
REACH requirement in Annex IX for a study on the bioaccumulation in
aquatic species is not needed if the substance has a low potential for
bioaccumulation and/or a low potential to cross biological membranes.
log Kow of Alchisor CAL 145 (as read-across from Alchisor CAL 123) is
presented as a range between 3.79 to >7.87 (with an average weighted
mean value of 7.71), however it considered that secondary poisoning is
unlikely to occur and the data requirement for CAL 145 is waived on the
basis of ready biodegradability, low toxicity to aquatic organisms and
the absence of toxicity to mammals. No
reliable measured bioconcentration information is available for Alchisor
chemically-similar Alchisor CAL 123 has been shown in the reliable
(Klimisch 1; Klimisch 2 when used for read-across) study by Schaefer and
Matthews (2010) to be readily biodegradable in water. The test substance
biodegraded to an extent of 87.7% after 28 days and although the
biodegradation rate just missed the 10-day window threshold, this aspect
of the test is not applicable to mixtures where different components of
the mixture can biodegrade preferentially (reference TG 103C). It
is assumed that Alchisor CAL 145 will readily biodegrade in the
environment and be unavailable for uptake and bioaccumulation in
to Aquatic Organisms
toxicity of the chemically-similar Alchisor CAL 123 to aquatic organisms
is very low based on the evidence presented in this dossier. The
lowest measured toxicity was based on an algal test where the NOEL based
on algal growth was 25 mg/L. Acute toxicity to invertebrates and fish
was >100 mg/L based on 50% mortality. Using
this evidence it is assumed that Alchisor CAL 145 represents a low
hazard and is not considered to be toxic (in PBT terms) to aquatic life.
CAL 123 is not considered to be toxic to mammals based on the evidence
presented in this dossier. Acute
oral and acute dermal toxicities in rat were > 2000 and >2020 mg/kg,
respectively based on the study by Kuhn (2010). Using this evidence it
is assumed that Alchisor CAL 145 is not considered to be toxic (in PBT
terms) to mammals and secondary poisoning is unlikely to occur in the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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