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EC number: 292-429-7
CAS number: 90622-29-0
CAL 145 comprises alkenes C13-14 hydroformylation products with
read-across from the chemically-similar Alchisor CAL 123 as defined in
the `Read-Across Justification Document'. Where
environmental toxicity data exist for Alchisor CAL 123, these are
representative of the Alchisor CAL 145 substance. In accordance with
REACH Annex IX, the requirement for studies of the effects on
terrestrial organisms is waived on the basis of unlikely direct and
indirect exposure of the soil compartment. In
addition, other evidence presented in this dossier on the substance's
ready biodegradability, low toxicity to aquatic organisms and the
absence of toxicity to mammals further support the waiver. No reliable
measured terrestrial ecotoxicity data are available for Alchisor CAL 145.
is unlikely that soil organisms will be exposed to Alchisor CAL 145 as
there is no intended use involving the direct application of Alchisor
CAL 145 to soil. In
addition, it is unlikely that indirect exposure will occur, via the
application of sewage sludge to land, as Alchisor CAL 145 is expected to
biodegrade through the sewage treatment process.
chemically-similar Alchisor CAL 123 has been shown in the reliable
(Klimisch 1; Klimisch 2 when used for read-across) study by Schaefer and
Matthews (2010) to be readily biodegradable in water. The test substance
biodegraded to an extent of 87.7% after 28 days and although the
biodegradation rate just missed the 10-day window threshold, this aspect
of the test is not applicable to mixtures where different components of
the mixture can biodegrade preferentially (reference TG 103C). It
is assumed that Alchisor CAL 145 will readily biodegrade in the
environment and sewage treatment processes and be unavailable for uptake
by soil organisms.
to Aquatic Organisms
toxicity of the chemically-similar Alchisor CAL 123 to aquatic organisms
is very low based on the evidence presented in this dossier. The
lowest measured toxicity was based on an algal test where the NOEL based
on algal growth was 25 mg/L. Acute toxicity to invertebrates and fish
was >100 mg/L based on 50% mortality. It
is reasonable to assume that Alchisor CAL 145 will also exhibit similar
toxicities to soil organisms resulting in a low hazard, which is not
considered to be toxic (in PBT terms) to terrestrial life.
CAL 123 is not considered to be toxic to mammals based on the evidence
presented in this dossier. Acute
oral and acute dermal toxicities in rat were > 2000 and >2020 mg/kg,
respectively based on the study by Kuhn (2010). Using this evidence it
is assumed that Alchisor CAL 145 is not considered to be toxic (in PBT
terms) to mammals and secondary poisoning is unlikely to occur in the
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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