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EC number: 212-133-3
CAS number: 764-99-8
Absorption by the oral, dermal and inhalation routes is expected. Moreover, distribution through extracellular body fluids is likely. Excretion will most likely occur via the urine. No bioaccumulation is expected.
analysis of 1,1'-[oxybis(ethyleneoxy)]diethylene (Diethyleneglycol
divinyl ether is liquid at room temperature with a molecular weight of
158.19 g/mol and an absolute density of 0.968 g/cm³ at 20 °C. The
substance has a melting point of – 21 °C and a boiling point of
191 °C. A water solubility for Diethylene glycol divinylether of 16 g/L
(20 °C) and a log Pow of 0.23 (25 °C) were determined.The
vapour pressure was estimated to be 0.3 mbar (20 °C).
on the low molecular weight, the moderate log Pow and a high water
divinyl ether is likely to be absorbed in the GI tract. As
it is a non-ionisable substance, absorption is independent of the pH
value which is present in the different GI sections. The vast amount of Diethyleneglycol
divinyl ether will be absorbed in the small intestine due to the much
larger surface area when compared to stomach.The log Pow
between -1 an 4 indicates that it will diffuse well across plasma
membranes. In addition, gastro-intestinal absorption of Diethyleneglycol
divinyl ether is triggered by passage via passive
diffusion through aqueous pores or carriage with the bulk passage of
water, which is favoured for small (molecular weight < 200 g/mol), water
soluble substances. It is unclear whether an active transport for Diethyleneglycol
divinyl ether exists. Overall, extensive gastrointestinal
absorption is expected for Diethyleneglycol
divinyl ether based on its physicochemical properties.
Moreover, numerous systemic effects seen in acute and repeated dose
toxicity studies after oral administration demonstrate and support that Diethyleneglycol
divinyl ether is well absorbed in the gastrointestinal tract.
Diethyleneglycol divinyl ether is a liquid with relative high water
solubility (16 g/L), a molecular weight well below 500 and a log Pow of
0.23, dermal absorption is likely, but lower than oral absorption as
Diethyleneglycol divinyl ether showed only mild effects when tested for
acute dermal toxicity.
divinyl ether exhibits a low volatility (vapour pressure of 0.3 hPa)
and a high boiling point
(> 190 °). Therefore, only a minimal amount of the substance is
available for inhalation. However, when vapour or particles reach the
alveolar region of the lung they are assumed to be absorbed directly
across the respiratory tract epithelium of the alveolar and capillary
membranes due to the log Pow > 0.
on the physicochemical properties (molecular weight: 158.19 g/mol, log
Pow: 0.23, water solubility: 16 g/L), Diethyleneglycol
divinyl ether is likely to be widely distributed
systemically throughout the extracellular compartments of the body after
due to the high water solubility and the moderate log Pow value below 3,
a long biological half-life in tissues can not be expected. Thus, Diethyleneglycol
divinyl ether has no bioaccumulation potential.
metabolism is determined by physicochemical factors like electronic and
steric effects within the molecule and/or by the presence of functional
groups. Phase II conjugation reactions like glucuronidation or
sulfatation might occur subsequent to Phase I reaction,e.g.after
introduction of a OH-group via Cytochrome P450 mediated oxidation.
Generally, metabolism will render the molecule more polar and harmless,
leading to faster excretion. No conversion into a metabolite that is
more toxic than the partent is expected as no
increases in toxicity where noted in the presence of metabolic
activation during the in vitro tests. Therefore, a clear
indication is given that the formation of reactive metabolites is
relatively high water solubility and the low molecular weight (< 200)
indicate that renal excretion is the most relevant route of systemically
available Diethyleneglycol divinyl ether.
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