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EC number: 212-133-3
CAS number: 764-99-8
No data are available on degradation rates in surface water and
sediment. According to the screening results of the OECD 301 B, the
substance is regarded as P/vP from a precautionary point of view.
Degradation products were predicted using a QSAR model. All 16
predicted metabolites have log Kow values clearly below the trigger
value of 4.5 (range: -1.7 to 0.23) and are considered as readily
biodegradable. Therefore, it can be concluded that none of these
degradation products is potentially PBT/vPvB.
In Article 13 of Regulation (EC) No 1907/2006, it is laid down
that information on intrinsic properties of substances may be generated
by means other than tests, provided that the conditions set out in Annex
XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR
results can be used if (1) the scientific validity of the (Q)SAR model
has been established, (2) the substance falls within the applicability
domain of the (Q)SAR model, (3) the results are adequate for the purpose
of classification and labeling and/or risk assessment and (4) adequate
and reliable documentation of the applied method is provided.
The criteria listed in Annex XI of Regulation (EC) No 1907/2006
are considered to be adequately fulfilled and, therefore, the
endpoint(s) sufficiently covered and suitable for risk assessment.
The degradation products were assessed using the QSAR model
CATALOGIC 301C v11.16 (OASIS Catalogic v126.96.36.199).
CATALOGIC 301C v11.16 (OASIS Catalogic v188.8.131.52) predicted 16
metabolites, identifyin two metabolites as relevant degradation products
in terms of PBT/vPvB assessment, with an estimated quantity of ≥ 0.1%
(for details see ‘Attached background material’ of the respective
Endpoint Study Record).
All metabolites have a log Kow ≤ 3, thereby not fulfilling the
screening criteria for bioaccumulation (B/vB) as laid down in Section
3.1 of REACH Annex XIII. In conclusion, all (relevant) predicted
metabolites are not expected to significantly accumulate.
Based on modeled data relevant degradation products present in
concentration of ≥ 0.1% (equivalent to quantity setting in OASIS
CATALOGIC: ≥0.001 [mol/mol parent]) do neither fulfill the PBT criteria
(not PBT) nor the vPvB criteria (not vPvB).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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