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EC number: 212-133-3
CAS number: 764-99-8
Long-term effects on aquatic invertebrates are not expected.
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of the substance (Q)SAR results were used for the estimation of the acute toxicity to aquatic invertebrates. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
The Expert Judgement (other information) was performed in order to support the evidence, that the substance is not expected to be chronically harmful to aquatic invertebrates. Further experimental studies are not provided.
Long-term toxicity of the substance to Daphnia magna was evaluated by the QSAR Toolbox v4.5 calculation model. The 21-d NOEC was determined to be 128 mg/L (BASF SE, 2022). The calculation was performed with the Trend analysis method and the substance was within the applicability domain of the calculation model. This result is supported by a QSAR calculation with KATE2020, which estimated a 21d NOEC for Daphnia magna of 110 mg/L (BASF SE, 2022). The substance was in the applicability domain of the model.
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